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What is Regenerative Medicine?

Using non-surgical cell repair therapies, Regenerative Medicine has the potential to heal damaged tissues and organs in patients, whose conditions may be beyond repair.

WHAT WE DO

 CellCore™ technology uses stem cells and other cell types to repair tissue debilitated by disease, damage, and even aging. Our expert physicians and scientists can easily concentrate and direct these stem cells, in a low-risk, outpatient treatment, providing remarkable h ealth benefits.. Regenerative therapy in Irvine Orange County includes several different medical procedures that all focus on using the body’s natural healing powers to aid in reducing pain. These procedures can include stem cells, platelet-rich plasma, exosomes, growth factors, and much more. Our providers use stem cells and platelet-rich plasma, specialized healing cells that are found naturally in the body. These cells are sent to the site of an injury after there has been damage to tissue. Stem cells and platelet-rich plasma tell the body to grow new, healthy tissue to replace the damage.  Stem cells and platelet-rich plasma are two of the most commonly utilized procedures in regenerative therapy. These cells can stimulate new cell growth in the body where damage has occurred. Once the healing process has begun, painful symptoms will subside, leaving a patient with less discomfort. The CellCore Regenerative Medicine Institute™, serving Irvine Orange County, has experience with stem cells derived from bone marrow, fat tissue, and amniotic fluid. These cells naturally occur and are the source of all the specialized tissues and organs of the human body. Platelet-rich plasma and stem cells have very similar healing properties. The platelets of blood plasma can also stimulate new cell growth through growth factors. Our group of providers has safely performed thousands of regenerative therapy procedures to reduce painful symptoms for our patients with stem cells and platelet-rich plasma. Regenerative therapy is a unique field of medicine that can stimulate the body’s natural healing process to reduce the symptoms of many painful ailments. The procedures used in regenerative medicine at R3 Stem Cell do not just cover up your pain with a generalized medication. These therapy methods target the damaged area of your body that is causing the pain. Pain medications are a one-size-fits-all solution that only provides temporary relief, doing nothing to heal your injury or health concern. Regenerative therapy is an alternative to invasive and costly surgical procedures as well. Your recovery time after a regenerative therapy procedure is typically much shorter than more invasive surgical procedures.

Irvine, California Orange County
Irvine is a beautiful coastal city in Orange County, California, where going to the beach is a daily activity for most. You can find people surfing and swimming all year round, as well as sunbathers just relaxing near the ocean. The closest, and most popular beach, is Newport Beach, where large waves and piers provide endless entertainment. This city also encompasses a large area of sycamore trees in Boomer that are thought to be ancient. These trails can be hiked, biked, and casually walked to enjoy the lush scenery of coastal California. Many residents of Irvine are extremely fit and active because the weather is almost always pleasant enough to be outside! This wonderful city is one of the happiest places in the United States and was named the second happiest city in 2019 by Business Insider.

 

Regenerative Medicine Irvine Orange County

Our team of board-certified specialists believe in the power of regenerative treatment. Regenerative medicine harnesses the body’s power to heal cells and tissues to treat pain, injuries, and conditions. As a leader in regenerative medicine in Orange County, we proudly offer a unique multidisciplinary approach to treat and heal patients’ symptoms. Regenerative treatments and procedures are safe and effective. Through our innovative treatments, we can naturally heal the patient without any potential risks or complications. Our specialists strive to relieve pain and rehabilitate the body with this natural alternative. We provide a personalized treatment plan through a comprehensive consultation. The doctor will perform a complete physical exam including a closer look at the damaged region to evaluate the impact of the injury, disease or condition. The physician will spend time educating the patient on all procedural and recovery details. Cellcore offers therapies that have been proven by medical research worldwide and by current, accurate, and authoritative data to be effective. They individualize the treatments to meet patients’ needs and monitor patients after they complete their treatment to ensure positive outcomes. The services provided include innovative regenerative medicine treatments like prolotherapy, platelet-rich plasma (PRP), immunotherapy, and intravenous (IV) infusion therapy, in addition to primary care.  Regenerative medicine is an area of modern medicine that has the potential to rejuvenate, replace, and regenerate tissues and organs. The human body has the ability to heal itself and fight illnesses through its immune system. It uses stem cells to produce more cells to replace damaged ones, and growth factors to restore tissues and organ functions. Regenerative medicine offers affordable health care solutions and healing that comes from within.

 

WHAT ARE STEM CELLS?

  By definition, stem cells are biologically undifferentiated cells that have the capability to grow into specific cells. All adult humans make their own supply of stem cells to replace degenerated tissue in their body when needed. This natural healing process is constant throughout adult life, although it can become less efficient in old age or as a result of repeated inflammation. Stem cells are special human cells that are able to develop into many different cell types. This can range from muscle cells to brain cells. In some cases, they can also fix damaged tissues. Researchers believe that stem cell-based therapies may one day be used to treat serious illnesses such as paralysis and Alzheimer disease.  Stem cells are unique cells: They have the ability to become many different types of cells, and they can replicate rapidly. Stem cells play a huge part in the body’s healing process, and the introduction of new stem cells has always showed great promise in the treatment of many conditions. It wasn’t until we found out where and how to isolate these cells that we started using them for transplants. Although a person’s own stem cells are always 100 percent compatible, there are risks in using someone else’s stem cells, especially if the donor and recipient are not immediately related. The discovery of certain markers allows us to see how compatible a donor’s and host’s cells will be. The relatively recent discovery of stem cells in the umbilical cord’s blood has proven advantageous over acquiring stem cells from other sources. Researchers are currently conducting clinical trials with stem cells, adding to the growing list of 80 diseases which they can treat. 

Your cells didn’t start out knowing how to come together to form your bones, heart or blood; they begun with more of a blank slate. These completely undifferentiated cells can be found during gestation, or the time the baby is in the womb, and are called embryonic stem cells. These early stage stem cells are master cells that have the potential to become any type of cell in the body.

First isolated in 1998, there is a lot of controversy around acquiring embryonic stem cells. Thankfully, we can also acquire stem cells that form just a little bit later down the road, like in the umbillical cord. These stem cells, known as adult stem cells, stay with us for life. (Later, we will learn why not all adult stem cells are equal.) Adult stem cells are more limited in the types of cells they can become, something known as being tissue-specific, but share many of the same qualities. Hematopoietic stem cells (Greek “to make blood” and pronounced he-mah-toe-po-ee-tic) found in the umbilical cord’s blood, for instance, can become any of the different types of blood cells found in the body and are the foundation of our immune systems. Another example is mesenchymal (meh-sen-ki-mal) stem cells, which can be found in the umbilical cord tissue and can become a host of cells including those found in your nervous system, sensory organs, circulatory tissues, skin, bone, cartilage, and more. To recap, we have certain types of stem cells that can become a variety of different cells—they are like the renaissance men of cells—but there is one more thing that makes stem cells special. This has to do with how they replicate themselves.

The body has two ways to create more cells. The first is usually taught in middle school science. Known as cell division, it’s where a cell replicates within its membrane before dividing into two identical cells. Cells do this as needed for regeneration, which we will touch on in a second.

The other way the body creates more cells is through its stem cells, and stem cells do things a little differently. They undergo what is called asymmetric division, forming not one but two daughter cells: one cell often an exact replica of itself, a new stem cell with a relatively clean slate, and another stem cell that is ready to turn into a specific type of cell. This trait is known as self-renewal and allows stem cells to proliferate, or reproduce rapidly. Through these two means, we are always producing more cells. In fact, much of your body is in a state of constant renewal because many cells can live for only certain period of time. The lifespan for a cell in the stomach lining is about two days. Red blood cells, about four months. Nerve and brain cells are supposed to live forever. This is why these cells rarely regenerate and take a long time if they do.  Different cells have different life cycles, and many are constantly regenerating, but when damage occurs and the body needs to come up with a new supply of cells to heal itself, it relies on the stem cell’s ability to quickly create more cells to repair the wound. Herein lays the potential for the introduction of new stem cells to enhance or be the driving factor in the healing process. Scientists first found ways to use stem cells in bone marrow, and following this discovery, the first stem cell transplant was performed in 1956 via bone marrow between identical twins. It resulted in the complete remission of the one twin’s leukemia. 

Further advancements were made in 1978, when stem cells were discovered in cord blood and in 1988, when cord blood stem cells were first used in a transplant. Stem cells extracted from the umbilical cord blood or tissue have since been shown to be more advantageous than those extracted from other sources such as bone marrow. In many ways, this is because stem cells from the umbilical cord can be considered naïve and immature compared to stem cells from other sources. Cord stem cells haven’t been exposed to disease or environmental pollutants, and they are more accepting of foreign cells. In this case, inexperience makes them stronger.

 This and all other stem cell therapies since involve introducing new stem cells into the area to encourage the healing process. Often, the stem cell will create a particular type of cell simply because it is in proximity to other cells of that type. Unfortunately, researchers still had a ways to go before they could use stem cells from unrelated persons.

Types of stem cells
Stem cells are divided into 2 main forms. They are embryonic stem cells and adult stem cells.

Embryonic stem cells. The embryonic stem cells used in research today come from unused embryos. These result from an in vitro fertilization procedure. They are donated to science. These embryonic stem cells are pluripotent. This means that they can turn into more than one type of cell.

Adult stem cells. There are 2 types of adult stem cells. One type comes from fully developed tissues such as the brain, skin, and bone marrow. There are only small numbers of stem cells in these tissues. They are more likely to generate only certain types of cells. For example, a stem cell that comes from the liver will only make more liver cells.

The second type is induced pluripotent stem cells. These are adult stem cells that have been changed in a lab to be more like embryonic stem cells. Scientists first reported that human stem cells could be changed in this way in 2006. Induced pluripotent stem cells don’t seem to be different from embryonic stem cells, but scientists have not yet found one that can develop every kind of cell and tissue.

Stem cells Therapy Irvine Orange County
The only stem cells now used to treat disease are hematopoietic stem cells. These are the blood cell-forming adult stem cells found in bone marrow. Every type of blood cell in the bone marrow starts as a stem cell. Stem cells are immature cells that are able to make other blood cells that mature and function as needed. 

These cells are used in procedures such as bone marrow transplants. These help people with cancer make new blood cells after their own hematopoietic stem cells have been killed by radiation therapy and chemotherapy. They may also be used to treat people with conditions such as Fanconi anemia. This is a blood disorder that causes the body’s bone marrow to fail.

Stem cells may help your health in the future in many ways and through many new treatments. Researchers think that stem cells will be used to help create new tissue. For example, one day healthcare providers may be able to treat people with chronic heart disease. They can do this by growing healthy heart muscle cells in a lab and transplanting them into damaged hearts. Other treatments could target illnesses such as type 1 diabetes, spinal cord injuries, Alzheimer disease, and rheumatoid arthritis. New medicines could also be tested on cells made from pluripotent stem cells.  Stem cell therapies are paving the way for more effective and minimally invasive treatments for many orthopedic conditions and injuries, and as a treatment for chronic joint pain. Cellcore Regenerative Medicine Irvine Orange County use stem cell therapy and regenerative medicine to treat sports injuries and orthopedic conditions in a broad range of patients, from professional and recreational athletes and highly active individuals to senior citizens and people suffering from workplace injuries.  Stem cells are undifferentiated cells, meaning they have the ability to develop into many different types of specific cells and tissue, such as skin or muscle, through a process known as differentiation., The cells divide to form the cells that perform very specific functions in the body, including which include bone, heart muscle, brain, and blood cells. There are both embryonic and somatic (adult) stem cells. In regenerative medicine, they can be used to replace diseased cells and tissue with new healthy tissue and cartilage. Additionally, more research into how the cells develop into other types of tissue can help researchers understand more about how the disease develops and progresses in the body.

DIFFERENT TYPES OF STEM CELLS
Mesenchymal Stem Cells (MSCs)
With the ability to develop into connective tissue, mesenchymal stem cells have been in use in medicine for over a decade, and are at the forefront of regenerative medicine applications for orthopedic conditions. MSCs can differentiate into bone, tendons, muscle, cartilage, and fat (adipose) tissue. Found primarily in bone marrow and skeletal tissue, mesenchymal stem cells have the ability to self-renew (regenerate). For people suffering from a degenerative joint disease like osteoarthritis, or the effects of a traumatic injury where irreversible loss of cartilage can lead to chronic pain and permanent joint damage, MSCs can be used to help restore the lost cartilage and prevent further damage to the joint.

Amniotic Stem Cells
Made up of a mixture of amniotic fluid and membrane, amniotic stem cells can differentiate into skin, muscle, cartilage, cardiac tissue, nerves, and bone. Through a process called amniocentesis, the cells can be safely extracted from the amniotic fluid for use in medical applications. Amniotic fluid also contains a large quantity of the mesenchymal type, and research is currently underway to further understand and develop how they may be used for successful organ and tissue regeneration.

Fat (Adipose) Stem Cells
Like the other categories of stem cells, these are derived from the fat tissue in the human body and have the potential to differentiate into different types of cells which can be used to help repair or replace damaged and unhealthy tissue. This type is especially promising because unlike mesenchymal and amniotic stem cells, which are derived from bone marrow and amniotic fluid and membrane, stem cells extracted from fat tissue can be extracted through procedures like liposuction, which has the added benefit of being a much simpler medical procedure.

WHY MIGHT IT BE RECOMMENDED?
Because of the nature of undifferentiated cells, they may help relieve or pain management related to various neuromuscular and degenerative disorders. This therapy may be recommended for patients with non-healing fractures or soft tissue injuries that aren’t healing as quickly as expected.

Affecting one out of every four Americans, arthritis can be difficult to manage effectively as tissues around joints become irritated and inflamed. Newer types of cutting-edge injectables are being used to help patients with certain types of arthritis, including osteoarthritis (OA). It may also be recommended for patients dealing with acute or chronic pain related to:

Non-herniated lower back discs
Partial tears of the rotator cuff
Meniscus and ACL tears and similar knee injuries
Stiffness, swelling, and tenderness around joints that’s affecting range of motion or mobility
Inflammation related to tendinitis and bursitis

The first step is to perform a thorough evaluation and several tests to determine the extent of the injury or the source of pain. Undifferentiated cells are typically collected from fat tissue in the back area or hips. They are separated from the collected tissue and prepared as an injection. Once the undifferentiated cells are ready, they are injected into the affected area. A local anesthetic is used to ease pain around the injection site.

This therapy is usually given as a series of injections during individual sessions spaced out over several days or a few weeks. Some patients may have an initial injection to see what the response is before any further treatments are scheduled. There may be some minor irritation or discomfort in the area where the injection was given, although this is usually temporary.

Considered a form of regenerative medicine, cutting-edge injectables for pain management purposes may improve the healing process enough to allow patients to enjoy greater benefits from different types of physical therapy, including treatments involving exercise to help restore flexibility, mobility, and range of motion. As is the case with orthopedic injections, it is generally considered safe since harvested cells come from the patient’s own body.  Cutting-edge injectables is simply the use of undifferentiated cells for healing and regenerative purposes. This is a non-surgical, outpatient treatment designed to instantly deliver help to areas where pain is being experienced due to damaged ligaments, tendons, muscle tissues, cartilage, or bone.

What this could mean for patients is a shorter recovery period and less painful rehabilitation. There’s also the possibility of avoiding surgery and reducing reliance on pain medications, including ones that may have potentially serious side effects or risks associated with long-term use.

 

 

the process

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STEM CELL THERAPY ORANGE COUNTY

A regenerative physician will determine the best method to effectively deploy the stem cells and deliver the new cells to the patient’s targeted tissues.

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